The only monographed poloxamer that is liquid at room temperature making it ideal for liquid dosage forms. Assessment of transdermal penetration enhancement by topical pharmaceutical excipients using skin pampa method m. Elastollan tpu technical data sheet elastollan 1185a polyetherbased grade elastollan 1185a is specifically formulated for extruded profile, sheet and film applications. Pdf poloxamers, poloxamines and polymeric micelles. Poloxamer 184 poloxamer 184 is a polyoxyethylene, polyoxypropylene block polymer. Poly ethylene glycol block poly propylene glycol block poly ethylene glycol you have selected the maximum number of product attributes 3 to compare. Nov 17, 2014 melting point nonproprietry name melting point c poloxamer 124 16 poloxamer 188 5257 poloxamer 237 49 poloxamer 338 57 poloxamer 407 5257 28.
Differential effects of commercialgrade and purified. Then, the impact of poloxamer 407 concentration on gel formation was evaluated. Password please note our services have been updated. We are the preferred supplier for your skin delivery solutions. Poloxamers and poloxamines are examples of biocompat. For certain active substances such as nifedipine, naproxen and fenticonazole as well as for essential oils in pharmaceutical formulations kolliphor p 407 is also used as a polymeric solubilizer. Formulation and characterization of rivastigmine loaded.
Assessment of transdermal penetration enhancement by topical. Basf s unparalleled portfolio of solubilizers and emulsifiers for topical products offers you the perfect solution, whatever the application or formulation type. Nonetheless, this important physical property of poloxamer 188 should be made available to pharmaceutical researchers as part of the risk assessment when using poloxamer 188 in formulation development. The adverse effects of these techniques are wellknown, and researches have been trying to find out new materials to occlude the coronary artery without an endothelial damage. Flexible excipient to overcome a wide range of pharmaceutical challenges that provide formulators with.
For protection from shear stress, poloxamer 188 has a long publication history as well as documented use in the manufacturing of approved biologics. Poloxamer 188, european pharmacopoeia ep reference standard. Rheology modifiers pdf, 859 kb rheology modifiers product recommendations for asia pacific pdf, 171 kb rheology modifiers product recommendations for europe pdf, 532 kb rheology modifiers product recommendations for north america pdf, 183 kb. The approximate lengths of the two peg blocks is 101 repeat units while the approximate length of the propylene.
Based on its pkpd ratios, doxycycline hyclate doxh, a timedependant antibacterial, is ideally expected to achieve both sustained plasma drug concentrations at or slightly above the mic level for as long as possible between dosing intervals. Us20274421a1 highly pure poloxamers and purification. The sales representative responsible for your area will be happy to answer any questions you may have about our products. You can find detailed information on our product range by looking up your industry or using our product finder. Publication of wo2009055312a1 publication critical patentwo2009055312a1en. Despite their wide range of applications, limited analytical techniques have been reported in literature for characterizing poloxamers and few are. The micrioemulsion based method was adopted for preparation of sln.
A 32 full factorial experiment was designed to study the effect of independent. Pluracare f127 finds application in toothpaste, whitening gels, mouthwash, sun and skin care applications. Effect of poloxamer 407 as a carrier vehicle on rotator cuff. Poloxamers are nonionic triblock copolymers composed of a central hydrophobic chain of. Basf corporation evaluation of lutrol f grades prill vs. Poloxamer 407 pluronic f127based polymeric micelles for. Pluracare l 64 is a copolymer of ethylene oxide and propylene oxide with an average molecular weight of 2,900. Journal of orthopaedic surgery and research effect of poloxamer 407 as a carrier vehicle on rotator cuff healing in a rat model soungyon kim 0 soowon chae juneyoung lee 0 department of orthopaedic surgery, hallym university kangnam sacred heart hospital, 9481, daerim1 dong, yeongdeungpogu, seoul 150950, south korea background. It exhibits excellent abrasion resistance, toughness, transparency, very good low temperature flexibility, hydrolytic stability and fungus resistance. Evaluation of hydrogels based on poloxamer 407 and polyacrylic. Ph eur usp nf jp poloxamer 407 jpe polyoxyethylene 196. Ibuprofen api dmfs us drug master file dmf details. There is a possibility that this would work better than injections.
Wo2009055312a1 process for producing a poloxamer gel. Coronary occlusion techniques during opcab may lead to an endothelial damage to the target vessel. Definition, structure and therapeutic applications in cancer. Effect of poloxamer 407 as a carrier vehicle on rotator cuff healing in a rat model. No, please bring me to the brochure download page now. In the present study, we investigate to the endothelial damage in the rat aorta which is occluded by poloxamer 407 gel. The word poloxamer was coined by the inventor, irving schmolka, who received the patent for these materials in 1973. Because the lengths of the polymer blocks can be customized, many different poloxamers exist that have slightly different properties. Download brochures this page features a selection of our latest brochures. Through science and innovation we provide our customers with products to meet the current and future needs of business and society.
A nonionic surfactant that has general functionality of surfactant, emulsifier, solubilizer and stabilizer. Narayan1 1technical service, basf corporation, roxbury, nj, 2pharmaceutical marketing, basf corporation, mount olive, nj introduction lutrol f grades are block copolymers referred to as poloxamers, consisting of polyoxyethylene. In vivo studies showing the effects of biologic healing. Poloxamer 407 is a hydrophilic nonionic surfactant of the more general class of copolymers known as poloxamers. Development of in situ poloxamerchitosan hydrogels for vaginal. Poloxamer 407 is a hydrophilic non ionic surfactant of the more general class of copolymers known as poloxamers. Pursuing this end, a poloxamer based matrix was used to produce a longacting injectable preparation doxhla and its serum concentrations vs. The ease of production, the stability at 4 c or at room temperature and the low cost of the formulation, when compared to the phospholipids used in the liposomal formulations, are attractive conditions. Strategy focused on participating in fast growing asian markets. About fagron fagrons strategy is focused on the optimization and innovation of pharmaceutical compounding. Fagron wants to widen the therapeutic scope of the. Poloxamer as an excipient authorstream presentation. Poloxamer is a common biopolymer in intradermal drugdelivery. Pursuing this end, a poloxamerbased matrix was used to produce a longacting injectable preparation doxhla and its serum concentrations vs.
Article information, pdf download for safety assessment of poloxamers 101, 105, 108. Effect of poloxamer 407 as a carrier vehicle on rotator. A supercritical fluid extraction process was used to prepare p188p. Higher molecular weight poloxamer has the ability to form thermoreversible gels. Basf corporation was supported on a polystyrene divinyl benzene solid matrix xad4. We are committed to maintaining the highest level of quality across the product spectrum. Thermogelling properties of purified poloxamer 407 sciencedirect.
The only monographed poloxamer that is liquid at room temperature making it. Pharmacokinetics of an injectable longacting formulation of. Pharmacokinetics of an injectable longacting formulation. Among the poloxamers, poloxamer 407 with registered trademarks of pluronic f127 by basf laboratories and. It possesses solubilizing, bodying and gelling properties. Poloxamer 407 about fagron fagrons strategy is focused on the optimization and innovation of pharmaceutical compounding. Poloxamers are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene polypropylene oxide flanked by two hydrophilic chains of polyoxyethylene polyethylene oxide.
Moisture content poloxamers generally contain less than 0. Humidity induced phase transformation of poloxamer 188 and. For example, the gelation temperature of poloxamer 407 is about 25 c and the gelation is affected by poloxamer grade. Supelco in a highpressure stainless steel vessel and extracted with carbon dioxide and modifying cosolvents approximately 4 mole % at 6,000 psi and 40 c. Safety assessment of poloxamers 101, 105, 108, 122, 123, 124, 181. Basf to develop a high purity poloxamer for mast therapeutics. Assessment of transdermal penetration enhancement by. Poloxamer 407 has approximate block lengths of a 101 and b 56. Quarterly statement pdf annual shareholders meeting 2020. Poloxamers are also known by the trade names synperonics, pluronic, and kolliphor. Basf maintains a drug master file for poloxamers at the fda and is familiar with.
Effects of temporary vascular occluder poloxamer 407 gel on. Yes, i would like to contribute to a better webbrowsing experience. Incorporating simvastatinpoloxamer 407 hydrogel into 3d. In particular poloxamer 407 lutrol f127 has been used in a number of applications, including ocular drug delivery7,8, where the increase in viscosity at body temperature increases the residence time of the drug on the eye. Basf, poloxamer 407 and poloxamer 188 being the most widely used in the literature. In addition to poloxamer 188 nf, basf also offers comprehensive solutions to the pharmaceutical industry for both small and large molecule formulation needs. Data on pluronic polyols, basf wyandotte corporation, herein incorporated by reference. Briefly, poloxamer 407 basf, ludwigshafen, germany was added to 0. The poloxamer 407 hydrogels were prepared as previously described. If you have further question, click the link below to send us an email. Ferguson recreation center in florida, usa, is using basfs melamine foam basotect to enhance acoustics for swimmers and visitors. Kolliphor p 188 is an poloxamer that enables and enhances a wide range of functional applications. Poloxamers are also known by the trade names synperonics.
With over 50 years experience in eopo chemistry, basf is committed to providing kolliphor p 188 bio, which is designed to meet your needs in quality, consistency, and performance in cell culture systems. List of drug master files dmf of ibuprofen active pharmaceutical ingredient api submitted to the u. It is a surfactant functioning both as cleansing and solubilizing agent. In the present study, we explored the potential of rivastigmine loaded solid lipid nanoparticle sln, as a new formulation in improving the bioavailability of antialzheimer drug rivastigmine which otherwise reported with poor bioavailability.
Process for producing a poloxamer gel download pdf. It exhibits excellent abrasion resistance, toughness, transparency, very good low temperature. Basf pharma ingredients and services offers our solutionsoriented skin delivery platform to formulators of otc and rx topical. Topical hydrogels of gentamicin were produced using poloxamer 407 and polyacrlic acids. Basf maintains a drug master file for poloxamers at the fda and is familiar with supplying. Kolliphor p 407 is used primarily as thickening agent and gel former, as well as coemulsifier and consistency enhancer in creams and liquid emulsions. The impurities of commercial grade poloxamer 188, as an example. Download fulltext pdf poloxamer hydrogels for biomedical applications article pdf available in pharmaceutics 1112. Pdf formulation of poloxamers for drug delivery researchgate. Trends and formulation strategies for topical drugs. Effects of temporary vascular occluder poloxamer 407 gel.
Basf maintains a drug master file for poloxamers at the fda and is familiar with supplying information to the fda to assist customers in obtaining fda authorization. The versatile melamine resin foam basf construction north. With over 50 years experience in eopo chemistry, basf is committed to providing the poloxamer kolliphor p 188 bio, which is designed to meet your needs in quality, consistency, and performance. Pdf poloxamers, also known as pluronics, are block copolymers of. Poloxamer complete drug information, side effects and. In vitro biological activity, toxicity and in vivo therapeutic efficacy against murine tegumentary leishmaniasis. If you decide to use photos or graphics belonging to inge gmbh, please clearly indicate this fact in the list of references or the image caption. English pdf, 627 kb superb foam with the pu fixed poker from basf. German pdf, 6 mb english pdf, 6 mb chemistry creates versatility. The components of poloxamer 188 solution basf is specialised in intermediates for rigid polyurethane foam and spray coatings for a multitude of applications. Us drug master file basf maintains a drug master file for poloxamers at the fda and is familiar with supplying information to the fda to assist customers in obtaining fda authorizations. Pdf poloxamer hydrogels for biomedical applications. Poloxamer 407 is a triblock copolymer consisting of a central hydrophobic block of polypropylene glycol flanked by two hydrophilic blocks of polyethylene glycol peg.
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